Omega 3-6-9: Do You Need It?

We've all heard that omega-3 or eating fish is good for us, and some of us might even interpret this to mean that all omegas are good, and therefore more = better.


January 15th, 2021

"I've heard omega-3 is good for me!" Therefore, Omega 3-6-9 is even better, right?

We've all heard that omega-3 or eating fish is good for us, and some of us might even interpret this to mean that all omegas are good, and therefore more = better.

Here's what we know:

  1. Omega-3 and Omega-6 fatty acids are ESSENTIAL fatty acids, meaning that our bodies cannot produce it and must obtain it from our foods or from supplements. On the other hand, our body can make its own omega-9 fatty acids from unsaturated fat.
  2. The ratio of omega-6 to omega-3 in our current Westernized diet is around 15:1. Studies suggest that our ancestors evolved eating a diet with a ratio of omega-6 to omega-3 of approximately 1:1.
  3. Omega-3s are anti-inflammatory, and omega-6s are considered pro-inflammatory. Both are required in the human body for normal, healthy physiological and immune function. However, this higher ratio favouring omega-6s has been postulated to lead to the development of many diseases, including cardiovascular disease, cancer, inflammatory, and autoimmune diseases . It has been suggested that many diseases of today are diseases of inflammation.
  4. While we don't know the ideal ratio of omega-6 to omega-3 for optimal health, a healthy ratio appears to be between 4:1 or 1:1. So, most of us should strive to increase omega-3 consumption while subsequently reducing omega-6 intake. Another reason we should increase omega-3 intake while decreasing omega-6 is that they both use the same enzymes for metabolism. A higher ratio of omega-6 would mean that there is less enzyme available to metabolize omega-3.

OMEGA-6 IS READILY ABUNDANT

Omega-6 is ubiquitous. It is present in safflower oil, sunflower oil, corn oil, "vegetable" oil and soybean oil. Almost all of the processed foods we buy today uses one or more of these oils. Most restaurants also cook and fry foods with one of these omega-6 rich oils (therefore, supplementation not needed in the general population). If we are using these oils in our home, then we further increase our omega-6 consumption.

OMEGA-3, NOT SO MUCH

On the other hand, most of us don't consume enough omega-3 rich sources of foods. The three most common omega-3 fatty acids are: ALA (alpha-linolenic acid), EPA (eicosapentaenoic acid), and DHA (docohexaenoic acid). DHA and EPA are commonly referred to as "fish oil" , as its most common source is fish and phytoplankton. Common terms for DHA and EPA also include “long-chain omega-3 fatty acids,” “seafood-derived omega-3 fatty acids,” and “marine omega-3 fatty acids.” Most of us get enough ALA from nuts, seeds, and cooking oils. And while ALA can be converted into EPA and DHA in the body, this process is not very efficient and so many of us do not get the EPA and DHA that we require for optimal health.

You can see here that almost all forms of dietary fat contain omega-9 (yellow), and many of them also contain some omega-6 (blue) fatty acids. ALA (orange) is only really present in flaxseed oil. However, flaxseed oil is cold-pressed and should never be heated or used for cooking.

So, we've discussed:

Omega-9: present in many forms of dietary fat, and is NOT essential (supplementation not needed in the general population).

Omega-6: many of the processed foods (i.e. snacks, takeout) we eat are prepared in omega-6 rich oils (therefore, supplementation not needed in the general population).

Omega-3: ALA is most easily obtained from nuts, seeds, and certain sources of dietary fats. Most of us have sufficient intake of ALA, but its conversion to DHA and EPA is low (roughly 10-15%) (supplementation not needed for ALA, DHA and EPA supplementation likely needed).

What are some benefits of DHA and EPA?

How much DHA and EPA do I need?

The best way to get EPA and DHA is through supplementation or through our diet. It's always best to try to obtain as much as you can through food (i.e. food first approach), then supplement if needed.

For general health, 250 - 500 mg of combined EPA and DHA is the minimum dose that has been recommended and can be easily obtained through fish intake. Again, this is the minimum dose suggested by many health organizations, not the dose for optimal functioning or health. Unlike vitamins and minerals, a general consensus or guideline for omega-3 consumption has not been established. Most health organizations tend to err on the side of caution - it is better to under-dose than to over-dose. According to the Panel on Dietetic Products, Nutrition and Allergies, "supplemental intakes of EPA and DHA combined at doses up to 5 g/day, and supplemental intakes of EPA alone up to 1.8 g/day, do not raise safety concerns for adults".

However, as with most recommendations in life - the amount of DHA and EPA needed is highly individualized and should take into account age, sex, diet, body mass, genetics, medication use, health status, and exposure to pollutants and toxins. These factors all affect how well someone metabolizes dietary fatty acids, and thus, their omega-3 status. This variability in omega-3 status also helps explain why there tends to be mixed results at the outcome of omega-3 research trials.

While there are omega-3 status blood tests available, it is beyond the scope of this blog post today. Nevertheless, for those that pursue this route, it is highly recommended to work with your primary care provider to determine a supplementation regimen, and to retest in 3 to 6 months to determine if adjustments need to be made.

The American Heart Association recommends one to two servings of seafood per week to reduce the risk of congestive heart failure, coronary heart disease, ischemic stroke, and sudden cardiac death, especially when the seafood replaces less healthy foods. For people with existing coronary heart disease, such as a recent myocardial infarction, the AHA recommends approximately 1 g/day EPA plus DHA, preferably from oily fish.

In the absence of omega-3 testing, the following general recommendations for omega-3 requirements have been suggested for those in generally good health and certain age status:

The FDA advises the general population not to exceed 3 g/day of EPA and DHA combined, with up to 2 g/day from dietary supplements, without the guidance of a clinician.

This is in addition to wild-caught fish or seafood consumption twice weekly, and decreasing omega-6 fat intake.

How do I choose a fish oil supplement?

  1. Choose supplements which contain DHA and EPA, not ALA.
  2. If you live in Canada, make sure to choose a product that has a Drug Identification Number (DIN) or a Natural Product Number (NPN) on the bottle. These numbers tell you that the supplement meets Health Canada’s guidelines.
  3. If you are allergic to fish or do not eat fish, consider an omega-3 supplement derived from algae.
  4. Look for Friend of the Sea, IFOS, non-GMO Verified certifications on your supplements.
  5. Some Cod Liver Oil supplements, while high in omega-3 fatty acids, may also contain Vitamin A, D, and E. These are fat-soluble vitamins that have the potential of accumulating in the body. So, it is something to be mindful of if supplementing with Cod Liver Oil.
  6. While there were previous concerns about increased risk of bleeding with omega-3 supplements, a recent 2020 systematic review of found that increased intake of long-chain omega-3 fatty acids did not increase the risk of bleeding.
  7. Always consult with your prescriber, pharmacist, or other health care provider before beginning any supplementation.

While we've barely scratched the surface about omega-3's, I hope you found this post useful! Curious about whether you may be deficient in any nutrients? If you want to optimize your health and way of eating, I can help to review your meals, coupled with your medical conditions and medications - to identify any drug-drug or drug-nutrient interactions and deficiencies (potential or actual). Just click here to learn more! Keep an eye out for future workshops as well!

- Janet

References:

  1. Avoid Vegetable Oils High in Omega
  2. Fish Oil and Perioperative Bleeding
    Emmanuel Akintoye, MD, MPH, Prince Sethi, MD, William S. Harris, PhD, Paul A. Thompson, PhD, PSTAT, Roberto Marchioli,  MD, Luigi Tavazzi, MD, Roberto Latini, MD, Mias Pretorius, MD, Nancy J. Brown, MD, Peter Libby, MD, Dariush Mozaffarian,  MD, DrPH
  3. Furman, D., Campisi, J., Verdin, E. et al. Chronic inflammation in the etiology of disease across the life span. Nat Med 25, 1822–1832 (2019). https://doi.org/10.1038/s41591-019-0675-0
  4. How Much Omega-3 Should You Take Per Day?
  5. Omega-3 Dosage: How Much EPA and DHA Should I Take?
  6. Omega-3 Fatty Acids: Fact Sheets for Health Professionals
  7. Patterson E, Wall R, Fitzgerald GF, Ross RP, Stanton C. Health implications of high dietary omega-6 polyunsaturated Fatty acids. J Nutr Metab. 2012;2012:539426. doi:10.1155/2012/539426
  8. Simopoulos AP. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother. 2002 Oct;56(8):365-79. doi: 10.1016/s0753-3322(02)00253-6. PMID: 12442909.
  9. Swanson, D., Block, R., & Mousa, S. A. (2012). Omega-3 fatty acids EPA and DHA: health benefits throughout life. Advances in nutrition (Bethesda, Md.), 3(1), 1–7. https://doi.org/10.3945/an.111.000893

Copyright © 2021 JCL Wellness.
All rights reserved.